The Duodenal Mucosal Bicarbonate Secretion Role of Melatonin in Neurohumoral Control and Cellular Signaling
نویسنده
چکیده
منابع مشابه
Role of Melatonin, Neuropeptide S and Short Chain Fatty Acids in Regulation of Duodenal Mucosal Barrier Function and Motility
Wan Saudi, W. S. 2015. Role of Melatonin, Neuropeptide S and Short Chain Fatty Acids in Regulation of Duodenal Mucosal Barrier Function and Motility. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1144. 89 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9369-1. The duodenal epithelium is regularly exposed to HCl, digestive enzymes, bacteria an...
متن کاملPeripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Melatonin is released from intestinal enterochromaffin cells and from the pineal gland, but its role in gastrointestinal function is largely unknown. Our aim was to study the involvement of intestinal and central nervous melatonin in the neurohumoral control of the duodenal mucosa-protective bicarbonate secretion. Working in anesthetized rats, we cannulated a 12-mm segment of duodenum with an i...
متن کاملNeuropeptide S reduces duodenal bicarbonate secretion and ethanol-induced increases in duodenal motility in rats
Alcohol disrupts the intestinal mucosal barrier by inducing metabolic and functional changes in epithelial cells. Recently, we showed that neuropeptide S (NPS) decreases duodenal motility and increases mucosal paracellular permeability, suggesting a role of NPS in the pathogenesis of disorders and dysfunctions in the small intestine. The aim of the present study was to investigate the effects o...
متن کامل5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca -dependent signaling pathways and 5-HT4 receptors in mice
Tuo, Bi-Guang, Zachary Sellers, Petra Paulus, Kim E. Barrett, and Jon I. Isenberg. 5-HT induces duodenal mucosal bicarbonate secretion via cAMPand Ca -dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol Gastrointest Liver Physiol 286: G444–G451, 2004. First published October 23, 2003; 10.1152/ ajpgi.00105.2003.—In previous studies, we have found that 5-hydroxytryptamine (5-HT...
متن کاملPhosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Prostaglandin E(2) (PGE(2)) plays an important role in the regulation of duodenal bicarbonate (HCO(3)(-)) secretion, but its signaling pathway(s) are not fully understood. In the present study, we investigated the signaling pathways involved in PGE(2)-mediated duodenal HCO(3)(-) secretion. Murine duodenal mucosal HCO(3)(-) secretion was examined in vitro in Ussing chambers by pH-stat titration ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003